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Dr. Stephen Girardin | University of Toronto 
Research: Excessive STING signaling as a novel pathophysiological process in Crohn's disease
Date: 2026-2029
Amount: $375,000

Crohn’s disease can be influenced by changes in genes that affect how the body responds to germs. This study focuses on a common change in a gene called ATG16L1, which is linked to a higher risk of Crohn’s. The research team believes this gene change may affect a pathway called STING, which helps the body respond to viruses and bacteria, and may lead to gut inflammation. By studying this process in human and mouse gut models, the team hopes to uncover new treatment options, including medicines that are already being studied for other diseases.